What helps "Nize" (pills)? Instructions for use, analogues


Do you know what helps "Nize" (pills)? If you do not possess such information, we will present it in the materials of this article.

from what helps nayz tablets

Packaging of the preparation and its composition

About what helps "Nize" (tablets), webelow. The active ingredient of this drug is nimesulide. Also in its composition it includes such components as microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, corn starch, magnesium stearate, sodium carboxymethyl starch, pineapple flavor and talc.

On sale, the drug in question comes in blisters of 10 tablets packed in packs of cardboard.

Principle of action of a medicinal product

Before answering the question of what helps "Nize" (tablets), you should tell us how this drug works.

According to the instructions, this is an NSAID, which is selectiveinhibits COX-2, that is, an enzyme involved in the synthesis of prostaglandins, mediators of pain, inflammation and edema. In addition to anti-inflammatory properties, the drug in question exhibits antipyretic and analgesic effects.

It is impossible not to say that this medicationinhibits (reversibly) the formation of prostaglandin E2 in the ascending pathways of the nociceptive system and the focus of inflammation, as well as in the ways of impulses (pain) in the spinal cord.

The drug "Naise", analogues of which are listedbelow, reduces the concentration of prostaglandin H2 (short-lived), from which, under the influence of prostaglandin-isomerase, prostaglandin E2 appears. Reducing the concentration of the latter leads to a decrease in the degree of activation of the receptors of the EP type (prostanoid), which is expressed in anti-inflammatory and analgesic effects.

analgesic nosis

It should also be noted that in a smallthe drug under consideration affects COX-1. Under physiological conditions, it almost does not prevent the occurrence of prostaglandin E2 from the arachidonic acid. This reduces the number of side effects of the drug.

The main properties of the drug (NSAIDs)

The drug "Naise" is able to suppress aggregationthrombocytes. This occurs by inhibiting the synthesis of thromboxane A2 and endoperoxides. In addition, it inhibits the release of histamine, and also reduces the degree of bronchospasm, which was caused by the effects of acetaldehyde and histamine.

Specialists have proven that nimesulide is goodsuppresses the synthesis of urokinase and interleukin-6, preventing the destruction of cartilaginous tissues. In addition, it inhibits the synthesis of metalloproteases, preventing the destruction of collagen and proteoglycans.

According to the instruction, by reducing the activity of myeloperoxidase, the drug in question exhibits antioxidant properties and slows the formation of products of (toxic) decay O2. It interacts with glucocorticoid receptors and activates them, which contributes to the enhancement of anti-inflammatory action.

nayz from temperature

Kinetics of the drug

After ingestion, the anesthetic "Naise" is absorbed from the intestine. Eating food reduces the rate of absorption of the drug, but does not affect its degree.

The peak concentration of nimesulide in the blood is reached after 2.6 hours. Its connection with proteins reaches 95%.

This drug penetrates into all tissues of the female genital organs. In addition, it is found in the acidic environment of the focus of inflammation and synovial fluid.

Metabolism of nimesulide is carried out in the liver. Its half-life is 5 hours. It is excreted mainly by the kidneys, and also along with the bile.

Indications for taking tablets

What helps "Nize" (tablets)? This means is prescribed for:

  • radiculitis, rheumatoid arthritis, sciatica;
  • lumbago, osteoarthrosis, articular syndrome with rheumatic disease and exacerbation of gout;
  • psoriatic arthritis, arthralgia, ankylosing spondylitis;
  • arthritis of various origin, osteochondrosis with radicular syndrome;
  • inflammations of ligaments, myalgia of non-rheumatic and rheumatic genesis, bursitis, inflammation of tendons;

    naid in pregnancy

  • pain syndrome of various origin (including trauma, postoperative period, toothache, algodismenorrhea, headache);
  • inflammations of the musculoskeletal system, as well as soft tissues.

Also it should be noted that the "Nyz" helps the temperature well. This drug is used for fever of various origins, including inflammatory and infectious diseases.

Contraindications NSAIDs

The drug "Naise" during pregnancy is prohibited. Also it should not be used when:

  • The "aspirin triad";
  • erosive and ulcerative lesions of the gastrointestinal tract (with exacerbation);
  • breastfeeding;
  • bleeding from the gastrointestinal tract;
  • impaired liver function;
  • in childhood to two years;
  • renal failure is severe;
  • hypersensitivity.

With special caution this agent prescribed for diabetes mellitus type, hypertension and cardiac insufficiency.

How to accept "Nyzes"?

The medicament in question in the form of tablets is administered only orally. Adult patients are recommended to take 100 mg twice a day. The maximum dosage of the drug per day is 400 mg.

how to take home

As for dispersible tablets,than to take such a medicine, it should be previously dissolved in 5 ml of ordinary water (in 1 dessert spoon). Use this remedy at the end of the meal or after eating.

Children do not prescribe the drug in tablets. For them, there is another form of medication - a suspension. It is recommended to take it at the age of two years.

Occasional phenomena

The drug "Naise", the dosage of which was presented above, can cause such undesirable reactions as:

  • heartburn, toxic hepatitis, nausea, thrombocytopenia, vomiting;
  • agranulocytosis, stomach pain, anemia, diarrhea, leukopenia;
  • erosive and ulcerative lesions of the digestive tract, headaches, increased activity of liver transaminases;
  • anaphylactic shock, dizziness, skin rash;
  • prolongation of bleeding time, bronchospasm, hematuria, fluid retention.
    Nize dosage

Cases of overdose

What are the symptoms of a largethe number of tablets "Nyz"? The dosage of this medication should be determined by the attending physician. If the medicine is accidentally swallowed (in large quantities), the patient may develop the following symptoms: convulsions, increased blood pressure, irritation of the gastrointestinal mucosa, impaired renal function, hepatic insufficiency and respiratory depression.

To eliminate such conditions, the patient is washed with a stomach, prescribed activated charcoal and conducts symptomatic therapy.

Drug Interactions

With simultaneous oral administration of the drug"Naise" with diuretics, "Digoxin", "Phenytoin", antihypertensive agents and lithium, as well as with other NSAIDs, cyclosporine, anticoagulants, methotrexate, hypoglycemic medications (inside), the patient may develop drug interactions (due to competing drugs for binding to proteins).

The drug "Naise": analogues and reviews

You can replace the drug under consideration with such medications as Nimulide, Aponil, Arkoksia, Mesulid, Meloksikam, Nimesil, Movalis, Nimesulid, Denebol, Nimika.


Most of the consumer feedback onthe preparation in question is of a positive nature. According to their opinion, "Nize" is quickly relieved of pain, and the drug is also used as a highly effective anti-inflammatory drug. Although some patients claim that this medication has one significant disadvantage. It very often causes such adverse reactions as dizziness, weakness and problems with the digestive system. In this case, doctors recommend to replace the drug with a similar remedy.